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Suriyaprakash, T. N. K.
- Formulation and Evaluation of Propanolol HCl Controlled Porosity Osmotically Controlled Tablet
Abstract Views :166 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, Periyar College of Pharmaceutical Sciences, K. Sathanoor Main Road, Tiruchirapalli-620021, IN
1 Department of Pharmaceutics, Periyar College of Pharmaceutical Sciences, K. Sathanoor Main Road, Tiruchirapalli-620021, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 6 (2010), Pagination: 378-380Abstract
The objective of the present study is to formulate once daily controlled porosity osmotic tablet of Propanolol HCl for the treatment of Hypertension and to reduce the pill burden by avoiding dosing frequency. Controlled porosity osmotic tablets have an advantage of avoiding cost and labor. Six batches (F1-F6) of osmotic tablets were made with Mannitol, KCl and NaCl as osmotic agent by wet granulation technique. The granules were evaluated for precompression properties. The granules were compressed into tablet using Rotary tablet compression machine. The tablets were coated with Ethyl Cellulose (F1E-F6E) and Cellulose Acetate (F1C-F6C) as coating polymer i.e. semipermeable membrane. The tablets were subjected to evaluation parameters like weight variation, hardness, friability, % weight increase for coated tablet and in-vitro dissolution using USP Type I apparatus. All batches compiles with pharmacoepial standards. Among the twelve batches F5C showed sustained release over a period of 20 hrs with 80.59% drug release. The best formulation was subjected to stability studies for 3 months 45°C and 70% RH.Keywords
Propanolol HCl, Controlled Porosity Osmotic Tablet, Ethyl Cellulose, Cellulose Acetate.
- Design and Development of Taste Masked Cefpodoxime Dispersible Tablets
Abstract Views :169 |
PDF Views:3
Authors
Affiliations
1 Department of Pharmaceutics, Al Shifa College of Pharmacy, Poonthavanam (P.O.), Kizattur, Perinthalmanna, Malappuram (Dt.), Kerala. Pin – 679 325, IN
1 Department of Pharmaceutics, Al Shifa College of Pharmacy, Poonthavanam (P.O.), Kizattur, Perinthalmanna, Malappuram (Dt.), Kerala. Pin – 679 325, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 1 (2017), Pagination: 239-244Abstract
Cefpodoxime proxetil (CP), a broad-spectrum cephalosporin antibiotic is used in this advanced era for treating acute bacterial infections. It has slightly bitter taste, poor water solubility and requires immediate release of drug from the dosage form, which serves the aim of fabricating CP as a dispersible tablet. The present study was undertaken to formulate taste masked cefpodoxime proxetil dispersible tablets by direct compression method. Different techniques for taste masking such as use of sweeteners and flavours, complexation with beta cyclodextrin and particle coating with stearic acid were studied. The blend was subjected to pre-compression studies such as angle of repose, bulk density, tapped density, compressibility index and Hausner ratio. After compression, the dispersible tablets were characterized using various tests such as hardness, weight variation, disintegration, water absorption, drug content, in vitro release, microbiological studies, taste evaluation and accelerated stability studies. The method of particle coating with stearic acid has shown excellent taste masking efficiency and flow properties for the powder blend. Different concentrations of stearic acid (2.5%, 5% and 7.5%) were used; out of which 5% stearic acid has shown better results. Antimicrobial assay proved that optimized formulation of CP dispersible tablet exhibits significant antimicrobial activity against Escherchia coli, Bacillus subtilis and Staphylococcus epidermidis.Keywords
Cefpodoxime, Dispersible Tablets, Stearic Acid, Taste Masking, Antimicrobial Assay.- Phytochemical Profiling and Pancreatic Lipase Inhibitory Activity of Flacourtia inermis Roxb. Fruits
Abstract Views :158 |
PDF Views:79
Authors
T. Bency Baby
1,
R. Murali
1,
T. N. K. Suriyaprakash
2,
V. V. Venkatachalam
1,
S. Vigil Anbiah
3,
N. Srinivasan
1,
V. Ajeesh
1
Affiliations
1 Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar, Chidambaram - 608002, Tamil Nadu, IN
2 Al Shifa College of Pharmacy, Keezhattur, Perinthalmanna, Malappuram – 679325, Kerala, IN
3 Central Animal House, Rajah Muthiah Medical College, Annamalai University, Annamalai Nagar, Chidambaram – 608002, Tamil Nadu, IN
1 Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar, Chidambaram - 608002, Tamil Nadu, IN
2 Al Shifa College of Pharmacy, Keezhattur, Perinthalmanna, Malappuram – 679325, Kerala, IN
3 Central Animal House, Rajah Muthiah Medical College, Annamalai University, Annamalai Nagar, Chidambaram – 608002, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 23, No 2 (2023), Pagination: 513-520Abstract
Objectives: The present research work was carried out to explore the potential use Flacourtia inermis [FI] fruits for the prevention and treatment of obesity through pancreatic lipase inhibition in vitro. The study also aimed to investigate the chemical profiling of ethanol extract of FI using High-Performance Thin Layer Chromatography (HPTLC), High-Resolution Liquid Chromatography (HR-LC/MS), and Nuclear Magnetic Resonance Spectroscopy (NMR). Materials and Methods: Dried fruits of Flacourtia inermis were pulverised and subsequently extracted using various solvents in sequential steps of increasing polarity, such as hexane, ether, chloroform, ethyl acetate, ethanol, and water. After phytochemical analysis by preliminary chemical testing various extracts were evaluated for their ability to inhibit pancreatic lipase, and the ethanol extract was found to have an IC<sub>50</sub> close to that of reference drug orlistat. The most potent ethanol extract was analysed by HPTLC and separated through column chromatography, and further analysis was performed by HR-LC/MS and 1H-NMR techniques. Results: The presence of various phytoconstituents in this plant was detected using different types of analytical techniques. PL lipase inhibitory activity was observed in extracts in a dose dependent manner. Performing PL inhibition assay, it was found that the ethanol fruit extracts have lipase inhibitory activity with an IC<sub>50</sub> value of 377.15 μg/ml. HPTLC finger printing of the ethanol extract showed the presence of various bioactice compounds. HR-LC/MS study of the most active ethanol extract indicated the presence of different phytochemicals, such as phenolics and flavonoids. Column chromatographic separation of ethanol fruit extract of FI followed by structural elucidation using various spectral studies demonstrated the presence of two compounds namely myricetin and quinic acid. Conclusion: The study suggests that the edible fruits of Flacourtia inermis have the potential to inhibit pancreatic lipase enzyme and therefore, may be recommended for the management of obesity. Additionally, our research sheds light on the phytochemistry of flacourtia species and may lead to the development of novel chemical entities as potential pancreatic lipase inhibitors.Keywords
Chromatography, Flacourtia inermis, Mass Spectrometry, Obesity, Pancreatic Lipase, Phytochemicals, NMR.Full Text
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